RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Adam17
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR;CCK-8 assays;western blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy
Year
2021
Function
"ADAM17 expression plays a key role in cardiac fibrosis by regulating endoplasmic reticulum stress and mitophagy, thereby limiting fibrosis and improving heart function."